Lab Describes Role of C-Reactive Protein in AMD

Thursday, October 6, 2016 - 08:15

A single nucleotide polymorphism in the complement factor H (CFH) gene is associated with an increased risk for the development of age-related macular degeneration. In this recent publication we showed that donor eyes homozygous for the high-risk CFH polymorphism have elevated monomeric C-reactive protein (mCRP) in the choriocapillaris compared to low-risk eyes. We also found that direct exposure to mCRP induces altered endothelial cell function in vitro and increased endothelial cell activation ex vivo.
This work was published in the Journal of Pathology (J Pathol. 2016 Oct;240(2):173-83. doi: 10.1002/path.4766. Epub 2016 Sep 19.)