Drug Screen for Macular Degeneration

Rab5a-Positive Endosomes in RF/6A Cells
Wednesday, October 31, 2018 - 15:00

Our lab recently published a paper describing the identification of compounds that protect the cells of the choroid (the vascular system that supports rod and cone photoreceptor cells) from injury by the complement system, a major source of cell injury in age-related macular degeneration.

Screening over 1,000 FDA approved compounds led to the identification of a class of molecules that provide a benefit to choroidal cells in culture, with the prospect that these (or related) compounds may be helpful in humans with macular degeneration.