![Local factor H production by human choroidal endothelial cells mitigates complement deposition: implications for macular degeneration](https://choroidlab.org/sites/mullins/files/styles/news_item_pic/public/news-pics/Complement%20System%20in%20AMD%2001-23-2022.jpg?itok=RsG9Reu1)
Sunday, January 23, 2022 - 15:30
Our lab recently published a new report on the role of local synthesis of the Complement Factor H gene product in protecting choroidal endothelial cells from deposition of the complement MAC complex, a major source of cellular injury in AMD. Kelly used immortalized choroidal endothelial cells and induced pluripotent stem cells to determine that local expression of the Factor H protein is sufficient to increase cellular protection.
https://onlinelibrary.wiley.com/doi/10.1002/path.5867