We actively collaborate with our colleagues in the Wynn Institute for Vision Research in the study of blinding diseases including Bardet-Biedl syndrome, Best disease, Stargardt disease, Leber congenital amaurosis, retinitis pigmentosa, choroideremia, glaucoma, and other acquired and inherited diseases of the retina.

Our laboratory employs a multidisciplinary approach involving donated human eyes, cell culture models including induced pluripotent stem cells, mouse models, and anatomical, molecular, and functional studies. It is our goal to use this knowledge to improve treatments and ultimately develop cures for the millions of individuals whose sight is threatened by retinal and choroidal diseases.

Recent News

  • Chirco Graduation 2017
    Mon, 05/15/2017 - 09:45

    The lab congratulates Dr. Kathleen Chirco, who received her PhD in Molecular and Cellular Biology with the dissertation, "Mechanisms of Pathophysiology and Methods for Regeneration of the Choriocapillaris in Age-Related Macular Degeneration" at The University of Iowa Graduate College Commencement on May 12th, 2017.

  • Thu, 05/11/2017 - 09:00

    In order to study endothelial cells of the choriocapillaris (CEC) replacement strategies we have generated a 3D choroid scaffold using a novel decellularization method in human RPE/choroid tissue. To our knowledge, this is the first report describing decellularization of human RPE/choroid, as well as recellularization of a choroid scaffold with CECs.

  • Tue, 10/18/2016 - 15:30

    The Iowa Lions Eye Bank recently published an article in their newsletter that highlighted the research being conducted in the Chorioretinal Degenerations Laboratory, specifically focusing on the Infant Globe Project.