In November, our laboratory published the first report detailing gene expression patterns of the human retinal pigment epithelium and choroid at the single cell level. We identified 11 categories (clusters) of cells, including melanocytes, Schwann cells and immune cells. Vascular endothelial cells showed distinct molecular profiles based on their location in the vascular tree, with unique capillary, arterial and venous patterns. In addition, eyes with macular degeneration showed higher expression of the gene RGCC, a potential target for future therapies.
Thursday, November 14, 2019 - 12:00
Wednesday, August 14, 2019 - 09:00
The lab recently published a study in which blood vessel density was examined in 143 human donor eyes with healthy aging, early stage age-related macular degeneration, and advanced "dry" macular degeneration (geographic atrophy).
Tuesday, July 9, 2019 - 16:00
In May of 2019, University of Iowa vision researchers published the first paper in the peer reviewed literature using single-cell gene expression within the human retina. With the aid of high-performance computing, the team was able to characterize gene expression profiles for 8,217 cells corresponding to ten different types of retinal cells. This multidisciplinary approach allowed for the first characterization of gene expression signatures in individual human retinal cell types such as photoreceptor cells and ganglion cells.
Thursday, May 9, 2019 - 15:30
Postdoctoral Research Scholar Kelly Mulfaul was honored with the 2019 Members-in-Training (MIT) Outstanding Poster Award in the Retinal Cell Biology category for her poster, “Choroidal Endothelial Cells Synthesize CFH Locally to Protect Against Complement Mediated Injury” at the annual meeting of the Association of Research in Vision and Ophthalmology in Vancouver, British Columbia, Canada.
Wednesday, October 31, 2018 - 15:00
Our lab recently published a paper describing the identification of compounds that protect the cells of the choroid (the vascular system that supports rod and cone photoreceptor cells) from injury by the complement system, a major source of cell injury in age-related macular degeneration.
Screening over 1,000 FDA approved compounds led to the identification of a class of molecules that provide a benefit to choroidal cells in culture, with the prospect that these (or related) compounds may be helpful in humans with macular degeneration.
Tuesday, April 3, 2018 - 14:30
Dr. Robert Mullins was honored with the Inaugural RPB David F. Weeks Award for Outstanding AMD Research from the Association of University Professors in Ophthalmology on January 26th, 2018 during the group's 2018 Annual Meeting in Austin, Texas.
Thursday, January 18, 2018 - 14:15
In collaboration with our colleagues in the University of Iowa Institute for Vision Research, we recently published a series of human retinal organ culture experiments to study the optimal type of viral vectors for transducing human retina. This study was published in Human Gene Therapy (Wiley et al., 2018, http://online.liebertpub.com/doi/10.1089/hum.2017.179). Photo courtesy of Dr. Luke Wiley.
Monday, May 15, 2017 - 09:45
The lab congratulates Dr. Kathleen Chirco, who received her PhD in Molecular and Cellular Biology with the dissertation, "Mechanisms of Pathophysiology and Methods for Regeneration of the Choriocapillaris in Age-Related Macular Degeneration" at The University of Iowa Graduate College Commencement on May 12th, 2017.
Thursday, May 11, 2017 - 09:00
In order to study endothelial cells of the choriocapillaris (CEC) replacement strategies we have generated a 3D choroid scaffold using a novel decellularization method in human RPE/choroid tissue. To our knowledge, this is the first report describing decellularization of human RPE/choroid, as well as recellularization of a choroid scaffold with CECs.
Tuesday, October 18, 2016 - 15:30
The Iowa Lions Eye Bank recently published an article in their newsletter that highlighted the research being conducted in the Chorioretinal Degenerations Laboratory, specifically focusing on the Infant Globe Project.