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We actively collaborate with our colleagues in the University of Iowa Institute for Vision Research in the study of blinding diseases including Bardet-Biedl syndrome, Best disease, Stargardt disease, Leber congenital amaurosis, retinitis pigmentosa, choroideremia, glaucoma, and other acquired and inherited diseases of the retina.

Our laboratory employs a multidisciplinary approach involving donated human eyes, cell culture models including induced pluripotent stem cells, mouse models, and anatomical, molecular, and functional studies. It is our goal to use this knowledge to improve treatments and ultimately develop cures for the millions of individuals whose sight is threatened by retinal and choroidal diseases.

Recent News

  • Thu, 11/14/2019 - 12:00

    In November, our laboratory published the first report detailing gene expression patterns of the human retinal pigment epithelium and choroid at the single cell level. We identified 11 categories (clusters) of cells, including melanocytes, Schwann cells and immune cells.

  • Labeling of healthy blood vessels (red) in a healthy eye (left) and an eye with geographic atrophy (right). Note the loss of choriocapillaris vessels (CC) in the eye with geographic atrophy.
    Wed, 08/14/2019 - 09:00

    The lab recently published a study in which blood vessel density was examined in 143 human donor eyes with healthy aging, early stage age-related macular degeneration, and advanced "dry" macular degeneration (geographic atrophy).

  • Molecular characterization of foveal versus peripheral human retina by single-cell RNA sequencing
    Tue, 07/09/2019 - 16:00

    In May of 2019, University of Iowa vision researchers published the first paper in the peer reviewed literature using single-cell gene expression within the human retina.